Join us on Twitter. Read about our approach to external linking. Sheffield City Council leader Terry Fox said: "This is absolutely devastating, just so incredibly sad. The horror crash happened on the A57 Sheffield Parkway at around 1.24am today. "And it is a day that we'll all remember because this doesn't happen in Killamarsh. Search by name. A woman has died after being found "on fire" in a Sheffield park. The Instagram account imjustsheff posted a video of the scene at High Hazels Park yesterday, the video showed crime scene investigators next to the cordon. Instead of using conventional drugs, which are inefficient in disrupting the stickiness of the SRSF1 protein, or invasive therapies to edit or modulate the activity of defective genes, the new study found that a small peptide incorporating a cell-penetrating module can stick to SRSF1 and effectively block the transportation of the rogue repeat RNA. Jenny Eells from BBC Radio Sheffield said people arrived to lay candles, flowers and teddies around a post in the centre of the children's playground. The BBC is not responsible for the content of external sites. "His mother was in the room with him," he said. MND is a debilitating condition that destroys the cells that control movement, leaving sufferers unable to move, walk, talk and eventually breathe. Enquiries are ongoing. A 42-year-old man and 44-year-old woman, both arrested on Monday, have now been released on bail. Welcome back Edit Account-Sign Out. There is no cure for FTD, and no treatments available to slow or stop the progression of the disease. 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A woman has died after being found "on fire" in a Sheffield park. WebSheffield & South Yorkshire. This research was pump-primed by a MND Association biomedical grant and further supported by UKRI through BBSRC and MRC New Investigator research grants. Ukrainian refugee family MND and FTD are devastating diseases which currently have no cure. This work has provided important evidence in support of a completely new strategy to treat the most common inherited cause of both MND and FTD, with the ultimate goal of developing effective therapies for these devastating diseases.. ", Derbyshire Police's chief constable Rachel Swann said the deaths were an "understandably shocking event that has deeply affected the local community in Killamarsh, as well as colleagues, family and friends in Sheffield. The death is not being treated as suspicious.". The BBC is not responsible for the content of external sites. A woman has been found dead at a flat in Sheffield after officers forced entry to the property. At the scene: Caroline Lowbridge, BBC News, 1894 shipwreck confirms tale of treacherous lifeboat. 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Scientists have found a novel way to block the transportation of mutant RNA and subsequent production of toxic repeat proteins which lead to the death of nerve cells in the most common subtypes of motor neurone disease (MND) and frontotemporal dementia (FTD). Follow BBC Yorkshire on Facebook, Twitter and Instagram. When I came here [outside] I saw the ambulance and police here. Mary E. Fisher Hallam. His family have been informed and are being supported by specially trained officers at this time. Local News. There had been concerns raised about the safety of the windows. news@thestar.co.uk. The Sheffield team previously discovered the abnormal transportation of the rogue RNAs copied from the C9ORF72 gene - known to be the most frequent cause of MND and FTD - is caused by excessive stickiness of a cell transporter named SRSF1. The BBC is not responsible for the content of external sites. Join us on Facebook. Instead of using conventional drugs, which are inefficient in disrupting the stickiness of the SRSF1 protein, or invasive therapies to edit or modulate the activity of defective genes, the new study found that a small peptide incorporating a cell-penetrating module can stick to SRSF1 and effectively block the transportation of the rogue repeat RNA. The new study, conducted by researchers at the University of Sheffields Institute of Translational Neuroscience (SITraN), also showed that using a peptide to stop the transport of mutant repeated RNA molecules and production of toxic repeat proteins actually increases the survival of C9ORF72 nerve cells - protecting them against neurodegeneration. Or by navigating to the user icon in the top right. The children's grandparents, Debbie and Trevor Bennett, also arrived at the scene to leave flowers. The Sheffield team previously discovered the abnormal transportation of the rogue RNAs copied from the C9ORF72 gene - known to be the most frequent cause of MND and FTD - is caused by excessive stickiness of a cell transporter named SRSF1. Sheffield, Yorkshire. WebThe Balance, 2 Pinfold Street. It is hoped the innovative research, conducted in collaboration with multiple labs in SITraN and with the groups of Dr Alexander Whitworth (University of Cambridge), Dr Cyril Dominguez (University of Leicester), Professor Frdric Allain (ETH Zurich) and funded by the MND Association and the UKRI BBSRC and MRC councils will transform the future of clinical trials for the most common forms of MND and FTD within the next few years. FamilySearch. "My thoughts just go out to the whole family," she said. Woodhouse murder: Suspected killers due in court over death of Sheffield woman Sarah Brierley Sheffield Star 11:38 28-Feb-23. Jason Bennett said he was heartbroken at the loss of daughter Lacey, 11, and son John Paul, 13, as he laid flowers at Chandos Crescent, Killamarsh. "As a council we are in close contact with the police and will provide any support that we can to the family - my heart goes out to them.". A five-year-old Afghan refugee who fell to his death from a Sheffield hotel window has been identified by police. WebSheffield Latest News | The Star Sheffield Parent seriously injured after large piece of cladding flies off school Culture strategy aims to bring millions in investment to city Plans Most patients with the disease are only expected to live two to five years after diagnosis. Read about our approach to external linking. For the latest Sheffield news, click here. She said officers were particularly keen to speak to anyone who was in Chandos Crescent between 21:30 BST on Saturday and 07:30 BST on Sunday, and had any information that could help with their investigation. He was later asked to accompany Mohammed's mother to hospital to translate. A cordon was in place in High Hazels Park, Darnall yesterday. We will however be open to any students who need our support. "I continue to appeal that anyone with information about Sarah's death gets in touch.". 4d. Emergency services were called to the OYO Sheffield Metropolitan Hotel on Wednesday afternoon, South Yorkshire Police said it was not treating the death as suspicious. This study was made possible thanks to donated tissue samples from the skin of MND patients which were reprogrammed into nerve cells. Subject taster sessions forY12 and Y13 students, Research centres, institutes and networks, Conferences, events, visitor accommodation and weddings, Support for refugee students and scholars, Scientists discover how to prevent death of nerve cells in most common forms of MND and dementia. South Yorkshire Police said: "Emergency services were called at around 3.45pm yesterday (Sunday, 25 April) following reports of concern for a woman in High Hazels Park, Sheffield. Sarah Brierley died from serious head injuries, police say, Police forced entry into the flat on Monday morning. Professor Guillaume Hautbergue, Professor of Translational RNA Biology at the University of Sheffield, who led the study said: When we tested our innovative approach by adding the peptide to the food eaten by fruit flies not only did the peptides block the damaging mutations which cause MND and FTD from being transported to the cell's nucleus, we actually saw an improvement in their neurofunction. It is home to Sheffield Wednesday and Sheffield United football clubs and the Crucible Theatre is home to the World Snooker Championships. 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